By Valery P. Kukhar, Harry R. Hudson
Aminophosphinic and aminoposphonic acids, man made analogs to average amino acids, have attained a place of prominence in research--particularly in learn regarding the amendment of physiological methods in residing organisms.
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Extra resources for Aminophosphonic and Aminophosphinic Acids: Chemistry and Biological Activity
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Another electron counting system classiﬁes ligands according to an ionic contribution. Both these systems are more completely described in a website found at http://www. html. Many stable coordination complexes can be counted as having sixteen electrons (16-e rule), especially those having square-planar geometry and those bonded to aromatic rings through their π electronic systems. Some of these complexes, belonging to a group of compounds called metallocenes, bind to DNA and have antitumor properties.
Some of these will be the bioinorganic chemistry topics treated in Chapters 5, 6, and 7 of this text. The recently coined term, proteomics, refers to the study of a large collection of proteins that occur and function together in a particular biochemical entity such as a cell or other organelle. Important interactions among proteins in a proteome distinguish the proteome’s behavior as being more complex than that of a single protein studied individually. A second major area of biochemical importance concerns study of nucleotide polymerization to produce ribonucleic acids (RNA) and deoxyribonucleic acids (DNA).